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Review von Polosa bescheinigt der E-Zigarette einen gesundheitlichen Mehrwert gegenüber des Tabakkonsums (03.01.2019)

Im Jahr 2019 hat Riccardo Polosa mit seinen Kollgen den Review: The effect of e-cigarette aerosol emissions on respiratory health: a narrative review veröffentlicht. In ihm bescheinigt er der E-Zigarette unter anderm einen gesundheitlichen Mehrwert gegenüber dem Rauchen. Er sagt aber auch, das mehr eindeutige Forschung in dem Bereich betrieben werden muss. Im Grunde belegt dieses Review aber bereits den Vorteil, den der Tobaco Harm Reduction- Ansatz beim Dampfen für die Raucher hat.

6. Conclusions

ECs generate respirable aerosols [16–18] containing glycerol, PG and their thermal degradation products (i.e. carbonyl compounds), chemical flavorings…The impact of switching to ECs on long-term respiratory outcomes is less clear. A 1-year randomized controlled trial of smokers with normal spirometry at baseline switching to ECs found no changes pulmonary function tests and reported improvements in respiratory symptoms (cough and shortness of breath) [119]. The study also observed progressive normalization of peripheral airways function (i.e. FEF 25–75%) among those who completely gave up cigarette smoking. Smokers switching from conventional cigarettes to combustion-free nicotine containing products (such as ECs) quickly and universally leads to normalization in exhaled CO levels [22,23]. When assessing respiratory health, it is of outmost importance to disentangle health effects driven by chronic exposure to EC aerosol emissions from those related to previous smoking history….In summary, the human subject studies provide the most relevant data on the effects of EC aerosol on human lung function, and several studies demonstrate potential benefits for smokers switching to EC. No studies reported serious adverse events, although the potential for such reactions cannot be completely excluded. Minor acute reactions have been reported, but it is not known if they are indicators of potential future lung disease, and no significant changes in pulmonary function were observed in short term trials. Smokers who substituted EC use for smoking experienced improvements in symptoms (cough, phlegm, etc.) and exhibited lower levels of exhaled CO, particularly for those with complete EC substitution. For smokers with diseases such as asthma and COPD, EC use appears to have a beneficial effect on symptoms. Yet to completely test the effects of EC on lung function, specific data is needed for each of the hundreds of e-liquid flavor combinations and the many different types of devices. This data can be provided by cell studies and animal models, but the current research designs must be substantially improved to yield accurate findings for determining the respiratory health risks and benefits of EC use by smokers. Last but not least, only large long-range prospective studies of vapers who have never smoked can provide definitive data to demonstrate any potential impacts regular use of vaping products may have on long term health.

Riccardo Polosa, Renée O’Leary, Donald Tashkin, Rosalia Emma & Massimo Caruso